Choose a substitute based on your desired flavor profile: smokiness, coarse texture, or heat intensity.
If using the DIY chili blend, mix paprika, cayenne, and smoked paprika in a 3:1:1 ratio until well combined.
Apply the substitute using the recommended ratios, adjusting cayenne pepper amount carefully due to its high heat.
Incorporate the substitute early during cooking for even flavor distribution or sprinkle crushed red pepper flakes later as a finishing spice.
Taste and adjust seasoning as needed to balance heat and smoky sweetness.